The incidence has two age peaks: one peak in the second and third decades affecting mostly women and a peak in the sixth and seventh decades affecting mostly men.
What groups of muscles are commonly involved?
The muscles affected are as follows, in order of likelihood: extraocular, bulbar, neck, limb girdle, distal limbs and trunk.
What is the differential diagnosis in case of Myesthenia Gravis?
· Botulism.
· Eaton-Lambert syndrome.
Mention a drug that can cause myasthenia.
o-Penicillamine therapy given for rheumatoid arthritis.
What is myasthenic crisis?
Exacerbation of myasthenia. The need for artificial ventilation occurs in about 10% of patients with myasthenia. Those with bulbar and respiratory involvement are prone to respiratory infection. The crisis can be precipitated by respiratory infection and surgery. Such patients should be closely monitored for pulmonary function. Those with artificial ventilation are not given cholinergics as this avoids stimulation of pulmonary secretions and uncertainties about overdosage.
How does a cholinergic crisis manifest?
Excessive salivation, confusion, lacrimation, miosis, pallor and collapse. It is important to avoid edrophonium in such patients.
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