As the dust settled on an emotion-filled Los Angeles memorial watched by up to one billion fans worldwide according to some estimates, attention returned Wednesday to the role of drugs in Jackson's tragic demise.
A dermatologist linked to the investigation into Michael Jackson's death denied giving the star dangerous drugs on Wednesday as mystery shrouded the King of Pop's final resting place.
Investigators are reportedly looking into five doctors who treated the superstar in the past and have zeroed in on a powerful sedative -- "Diprivan" -- discovered at Jackson's rented mansion after his death.Jackson's long-time dermatologist Arnold Klein on Wednesday denied he was the source of the drugs found but said he had often been concerned other medical professionals were supplying the singer with medications.
"I didn't give him this crap that they're talking about," he told ABC television's Good Morning America. "How am I going to prescribe Diprivan when I don't understand how to use it?"
"I say that anyone who makes someone an addict or gives a person potentially dangerous substances directly to them to use, like propofol is a criminal," Klein said, referring to the generic name for Diprivan.
Source: Yahoo News
Here question arises that what is Diprivan,what is its main action and how does it acts?
What is Diprivan?
Diprivan is used to start or maintain anesthesia during certain surgeries, tests, or procedures.Diprivan is a general anesthetic.
The structural formula is as follows
A dermatologist linked to the investigation into Michael Jackson's death denied giving the star dangerous drugs on Wednesday as mystery shrouded the King of Pop's final resting place.
Investigators are reportedly looking into five doctors who treated the superstar in the past and have zeroed in on a powerful sedative -- "Diprivan" -- discovered at Jackson's rented mansion after his death.Jackson's long-time dermatologist Arnold Klein on Wednesday denied he was the source of the drugs found but said he had often been concerned other medical professionals were supplying the singer with medications.
"I didn't give him this crap that they're talking about," he told ABC television's Good Morning America. "How am I going to prescribe Diprivan when I don't understand how to use it?"
"I say that anyone who makes someone an addict or gives a person potentially dangerous substances directly to them to use, like propofol is a criminal," Klein said, referring to the generic name for Diprivan.
Source: Yahoo News
Here question arises that what is Diprivan,what is its main action and how does it acts?
What is Diprivan?
Diprivan is used to start or maintain anesthesia during certain surgeries, tests, or procedures.Diprivan is a general anesthetic.
The structural formula is as follows
What is its main action and how does it acts?
Propofol (2, 6-diisopropylphenol) is a short-acting general anaesthetic agent with a rapid onset of action of approximately 30 seconds. Recovery from anaesthesia is usually rapid. The mechanism of action, like all general anaesthetics, is poorly understood. However propofol is thought to produce its sedative/anaesthetic effects by the positive modulation of the inhibitory function of the neurotransmitter GABA through the ligand-gated GABAA receptors.In general, falls in mean arterial blood pressure and slight changes in heart rate are observed when DIPRIVAN is administered for induction and maintenance of anaesthesia. However, the haemodynamic parameters normally remain relatively stable during maintenance and the incidence of untoward haemodynamic changes is low.DIPRIVAN reduces cerebral blood flow, intracranial pressure and cerebral metabolism. The reduction in intracranial pressure is greater in patients with an elevated baseline intracranial pressure.
Pharmacokinetics
The decline in propofol concentrations following a bolus dose or following the termination of an infusion can be described by a three compartment open model.
The decline in propofol concentrations following a bolus dose or following the termination of an infusion can be described by a three compartment open model.
The first phase is characterised by a very rapid distribution (half-life: 2 to 4 minutes) rapid elimination (half-life: 30 to 60 minutes) and a slower final phase, representative of redistribution of propofol from poorly perfused tissue.
Propofol is extensively distributed and rapidly cleared from the body (total body clearance 1.5 to 2 L/min). Clearance occurs by metabolic processes, mainly in the liver, to form inactive conjugates of propofol and its corresponding quinol, which are excreted in urine.
When DIPRIVAN is used to maintain anaesthesia, blood concentrations asymptotically approach the steady-state value for the given administration rate. The pharmacokinetics are linear over the recommended range of infusion rates of DIPRIVAN.
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