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Monday, January 31, 2011

Download Prostate Cancer, 1st ed. 2009 book free

Prostate Cancer
(Contemporary Issues in Cancer Imaging)
Hedvig Hricak and Peter Scardino
ISBN-10: 0521887046
ISBN-13: 978-0521887045
Cambridge University Press




A multidisciplinary disease management approach is critical in this disease. For the radiologist, understanding the pathophysiology, critical clinical issues, and advantages and limitations of different treatments is essential for meaningful interpretation of imaging studies. Similarly, for the practicing clinician, understanding the advantages and limitations of imaging modalities and the importance of optimal technique are crucial to the rational use of imaging. This volume serves as a valuable reference for radiologists, urologists, medical and radiation oncologists and all practitioners involved in the management of prostate cancer.

USMLE question No. 1: A 67-year-old woman presents with a 4-week history of headaches, facial pain, blurred vision, and intense pain ...

A 67-year-old woman presents with a 4-week history of headaches, facial pain, blurred vision, and intense pain and stiffness in her shoulders and hips. She is diagnosed with a vasculitis, and a biopsy of an affected artery is taken. Histological examination is most likely to reveal which of the following characteristic findings?

(A) concentric “onion skin” thickening and fibrosis
(B) extensive intra- and extravascular granulomatous inflammation
(C) fragmentation of the internal elastic lamina with giant cells
(D) hyaline arteriolosclerosis and luminal narrowing
(E) segmental fibrinoid necrosis and neutrophil infiltration

Answer:
C:
The most likely diagnosis in this case isgiant cell (temporal) arteritis; it is both the most
common systemic vasculitis in this woman’s age group (>60) and is suggested by the clinical
history. Giant cell arteritis may affect any medium- and large-sized arteries, but principally
involves vessels in the head, that is, extracranial branches of the carotid arteries.
Vascular insufficiency leads to symptoms of jaw or facial pain, headaches, and visual
changes, as reported by this patient. In particular, ischemic optic neuropathy may occur
abruptly, resulting in permanent blindness; for this reason, patients with ocular disturbances in
suspected cases demand immediate medical intervention. Temporal arteritis has a strong,
well-known association with polymyalgia rheumatica, a systemic inflammatory disorder
causing symmetrical, often severe muscle pain and stiffness in the shoulders and pelvic girdle
(also reported by this patient); both conditions are associated with the HLA-D4 haplotype.
Microscopically, a section of a vessel affected by giant cell arteritis will demonstrate fragmentation of the internal elastic lamina and the presence of multinucleated giant cells.
Concentric “onion skin” thickening and fibrosis (choice A) may be seen most commonly in
malignant hypertension but also in other conditions such as primary sclerosing cholangitis.
Extensive intra- and extravascular granulomatous inflammation (choice B) refers to
Wegener granulomatosis which often includes:
(i) acute necrotizing granulomas of the upper
and/or lower respiratory tract;
(ii) granulomatous
vasculitis; and
(iii) renal disease.

Hyaline arteriolosclerosis and luminal narrowing (choice C) is found in association with benign hypertension and in diabetes mellitus but is also seen in some normotensive, nondiabetic elderly individuals. Segmental fibrinoid necrosis and neutrophil infiltration (choice E) is a description of the acute phase of polyarteritis nodosa.

Sunday, January 30, 2011

Download Treatment Planning in Radiation Oncology, 2nd ed. 2007 free

Treatment Planning in Radiation Oncology
Faiz M. Khan

ISBN-10: 0781785413
ISBN-13: 978-0781785419
L W W




Completely updated for its Second Edition, this text is a comprehensive guide to state-of-the-art treatment planning techniques in radiation oncology. The book provides the treatment planning team—radiation oncologists, medical physicists, and medical dosimetrists—with detailed information on both the physics of radiation treatment planning and the clinical aspects of radiotherapy for specific cancers. More than 600 illustrations provide practical examples of the methodologies. Brand-new chapters in this edition cover image-guided radiation therapy, high dose rate brachytherapy, and brachytherapy treatment planning algorithms. The chapters have been completely updated, particularly in areas including intensity-modulated radiation therapy and brachytherapy.


Frequently Asked questions about United States Medical License Examination (USMLE)

Q1: What is USMLE and what's the difference between it and the ECFMG?
Answer: USMLE is an abbreviation of UNITED STATES MEDICAL LICENSE EXAMINATION, it allows you to have a medical license to practice medicine in USA, it consist of series of examinations which when you finish, you will get the USMLE certificate, however, this is applied to the USA and CANADA medical college graduates only who can apply for residency (neyaba) right after finishing the exams with the guarantee of having a place in it (97% of the USA and CANADA medical graduates join the residency program)

The ECFMG is the Educational Commission for Foreign Medical Graduates (ECFMG), it's the same as the USMLE STEPS, but it's related to those who apply for the USMLE exams from outside USA and CANADA. After a foreign medical graduate finished ECFMG, he should apply for residency program on his own with a chance of succeeding or failing with NO guarantee (only 45% of foreign medical graduates succeed in applying for the residency program).


Q2: what are the USMLE steps? Or how can I get the USMLE certificate?
Answer: USMLE examination is composed of 3 steps, only 2 of them are necessary to get the ECFMG certificate.
They are
USMLE step1: it's composed of 7 categories, each category have 50 mcq in the exam, so the total is 350 mcq the content of the exam, the categories are
1-physiology 2- biochemistry, 3-anatomy and histology(both in one category), 4- pharmacology, 5-pathology, 6- microbiology and parasitology( both in one category), 7- behavioural science however, there are few topics that have no categories but is also included: genetics, aging, immunology, nutrition, and molecular and cell biology. STEP 1 can be examined outside USA, and this exam has score.

USMLE step 2: it's composed of 2 sectors:

Sector 1: step 2 CK ( Clinical Knowledge) :- it's related with the clinical part of the medical study but without a physical examination, so it can be examined outside USA, it has score as well as step 1. More details for this exam is discussed as follows:
It consists of multiple-choice questions. Test questions focus on the principles of clinical science that are deemed important for the practice of medicine under supervision in postgraduate training.

Sector 2: Step 2 CS (Clinical Skills): this is the physical part of the clinical examination which must be examined in the USA as a one day exam, multiple patients are examined in a limited time with a pass or fail policy ( no score in this exam). For more details on this part you can visit this link
http://www.usmle.org/step2/Step2CS/S...ep2CSIndex.htm

step 3: It's not required for the ECFMG certificate and it's not included in it, also, it's not conditioned on any period (after 2005 the majority of states ask the applicant to finish step 3 before residency interview or in the first year of residency ) for more information on step 3 visit this link
http://www.usmle.org/step3/default.htm


Q3: what can I get after I finish the USMLE steps?
Answer: When you finish step1, step 2 CK, step 2 CS. You'll get the ECFMG certificate which will allow you to apply for the residency program in USA. However, you should be aware that *the ECFMG doesn't allow you to work in other countries than USA, it also doesn't allow you to work in the USA till you finish the residency program and get the license.


Q4: what is the residency? And how can I apply to it's program?
Answer: The residency is the period in which the medical student graduate practices medicine but under supervision for a period of time extending from 3 years minimum to 7 years maximum with sufficient payment that differs from one hospital to another depending on the agreed contract. The period of the residency is depends on the speciality one wish to continue on in his post-graduates.
Note that residency program qualifies the person to work in the USA as a licensed medical physician. It's not a full time Job, after finishing residency you'll get your license and a visa that allows you to stay in the USA.
TO APPLY in the residency you must have the ecfmg certificate if you don't have American or Canadian nationality and not a graduate of American or Canadian medical college.
For more information about the residency you can visit the site
www.ecfmg.org
Or visit Amedeast centre in cairo 23-mosaddak street , Dokki


Q5: what is the cost of the whole Career when I Start it from Pakistan?
Answer: Step 1: the cost of usmle step 1 in Pakistan is $780 - Examination Fee + International Test Delivery Surcharge, if testing outside the United States and Canada ,
For step 2 ck; $780 - Examination Fee+ International Test Delivery Surcharge, if testing outside the United States and Canada if the exam in Pakistan,
For step 2 cs : $1,355 - Examination Fee in the usa, for examination in other countries please visit
http://www.ecfmg.org/fees.html

Q6: How do I prepare for the test? Is there a review book on USMLE?

Answer: Many resources are provided for USMLE, not a single one of them is recommended by the exams center, so you can study from any source you like, but the recommended books for STEP 1 that are available are:
1-Kaplan collection (180LE) + video DVDs
2-UCV series.
3-HIGH Yield series.
4-First aid book evaluation for Step 1 books.
http://www.mediafire.com/?cxyzml0990d

For Qs:

1- USMLE WORLD Q BANK (the best).
2- NMBE forms.

For step2, the same resources are available.

Q7: why people say that USMLE Exam is so difficult?

Answer: Preparing for the USMLE is very essential, not only with informations, but also with skills and interpreting the tricky questions, so it needs lots of practice from more that one source of either informations or exams.
But its not hard itself, the difficulty is the Risk of the experience itself, but many people managed to go through all this and challenged everything in order to reach their goal and they did.

Q8: How do I apply for the examinations? And when should I do this?

Answer: For ECFMG, you must apply with Credit card by the net, the official site is
www.usmle.org
There's provided bulletins of informations for the date of the exam, however, you can change your exam date before 3 mounths of it's time without loosing your money, but you can't take back your money if you changed your mind after you paid it, so you must have enough complete inforamtions about the payment method and the rules.

Step 1 can be taken after studying the already mentioned categories, no certificate is needed for applying for this exam.

Step 2 CK can be taken for after studying the already mentioned categories as step1, no certificate is needed for this exam

Step 2 CS can be taken only after aquiring a certificate from the medical college of the country the person applies from, for example, if the applier is from so a certificate from a medical college that is recognized by the world health organization which indicated that the applier has finished studying all medical materials.

Q9: Can I retake a Step that I passed to raise my score?

Answer: If you pass a Step, you are not allowed to retake it, except to comply with the time limit of a medical licensing authority for the completion of all Steps or a requirement imposed by another authority recognized by the USMLE program.

Q10: Can I apply for Step 2 CK or CS before Step 1? And what is the period allowed to finish step 1 and step 2 ck and cs?

Answer: Yes, it's allowed, no order is needed in those exams, the period allowed to finish step 1, step2 CK, and step 2 CS is seven years starting from the date of the payment of the first exam.

Q11: If I decided to start USMLE step 1, is there any recommended time table to take it in the summer vacation during My college study?

Answer: The recommended hours for step1 a person who already taken the materials in his college: at least 230 hours. This 230 hours can be distributed on 45 days with 5 hours daily. Also DVD lectures can be listened to in this timetable. The priority in this timetable according to the time needed will be as follows
1-physiology (100 hours)
2-anatomy and histology (35hours)
3-biochemistry (35 hours)
4-pathology (30 hours)
5-pharmacology (30 hours)
6-microbiology (20 hours)
7-behavioural science ( 10 hours)

After that, you must prepare yourself for the exam with many resources for Questions which are available in DVDs as well as the network, you must prepare your self for at least 40 hours in the form of MCQ examinations on the above materials.

However, Experiences say that it's PREFERABLE to take Step1 real exam after graduation from College and even after taking Step2. this is simply because Step1 have not less than 50% clinical Question, and that would be difficult for those who only took academic years and didn't study clinical differential diagnosis.
Nevertheless, you can Study Step1 and test yourself during summervacations, but with Simulation exam not real one, this would add to your experience and skill in dealing with USMLE examination when you apply after graduation.

Q12: what are the disadvantages of USMLE examination?

Answer: 1-very expensive test;

2-Once you passed a test, you can't retest again, the score you got is the one you'll have and you can't modify it, even if you got exactly the passing score, and that's not good for competition in residency.

3-You have only 7 years to finish the three tests USMLE 1, 2CK, 2CS, if you finished 7 years without finishing a single test of them, your pervious score in previous test you passed will be disregarded and you can't test USMLE again for ever.

4-the biggest disadvantage of all is the RISEDENCY program conditons, you must do more than one interview in all health facilities in different states in USA because each one has it's own conditions that differ from others, and this for you will be MASS competition with the whole world, doctors from all over the world will apply just like you, and it would be a matter of who's the best, there will be desires that you'll fill, and of course the desire of any speciality you want will determine the post graduates study that you'll continue on, for example, if you choose pediatrics as first one, then choose many others and the last is Radiology, if they need Radiology and there's someone better than you got applied for pediatrics also as first desire, they would take him not you, and you may take Radiology even if it's the last thing you want

5-many people had post-graduate studies in orthopedic, and went on usmle to find themselves in ENT, it's very wild competition out there.

6-USMLE Step 2 cs (clinical skills), is only 15minutes for each single patient, you must give detailed history for the patient in 15 minutes, so you must have good English and fast analyzing, but with all that, there's no score in that test, either pass or fail, so you don't know the examiner, he might consider you failed before you even have your exam

7-ONLY 45% of the people of the world who join ECFMG program or usmle success in applying for any residency even if they don't want it (47% in 2007) the other 55% just return home, the score of step1, step2 ck is considered in residency, also recommendation letters are considered, your race is not officially considered but as an Arabic muslim you should be aware especially after 11/9 events.


Q13: what are the resources for the above information?

Answer: The main resource is Amedeast center 23 Mosaddak street el Dokki,there is twice a month sessions for medical USMLE, the session is 40LE

Sites for USMLE
www.usmle.org
www.ecfmg.org
www.prometric.com.

Q14: what are the latest news about USMLE in general, and what its impact as a whole? (updated answers)

I- A new center was established in Dubai for Step2 CS examination, this is due to agreements between USA and UAE, by which any examinee in the world can take step2 CS test in Dubai instead of USA. This was originally made to reduce the flood of the Asian applicants to the USA, also its diverting attention to the USMLE by the Gulf Medical students.

the Impact of this News on IMGS:
1-first its useless because IMGS spend almost the same costs in travelling ticket to Dubai, and the cost of the exam is the same.
2-When taking Step2CS in USA, that would be good advantage for getting VISA for travelling again to the matching for residency, because being in the USA before is advantage in VISA preceedures. but now after UAE exam it would be even more difficult for those who took Step2cs in dubai to get VISA for travelling to USA
3-for the rest of Medical students outside Gulf area that look for work in the future in Gulf area, this is self depending from the gulf area to promote their local medical students and encourage them to take usmle so that they don't need workship from outside their countries.

Saturday, January 29, 2011

A case study of 62 year old female having atrial fibrillation, MI, and fracture of femur

A 62-year-old woman has had atrial fibrillation since experiencing a myocardial infarction (MI) 7 months prior. Two weeks ago she was hospitalized following a car accident in which she suffered a compound fracture of her left femur and several severe contusions. She now returns to the emergency room with right flank pain, hematuria, and left-sided paralysis. These newly developing problems are most likely the result of which of the following?

(A) air embolism from the compound fracture
(B) bone marrow embolus from the fractured femur
(C) fat embolism from the fractured femur
(D) systemic thromboemboli from the left atrium
(E) venous thromboemboli from the deep leg veins

ANSWER:
D:
Atrial fibrillation produces turbulence that is conducive to the formation of thrombi which can then embolize throughout the systemic circulation. In this patient the right flank pain and hematuria and left-sided paralysis suggest that thromboemboli traveled to the right kidney and the brain, respectively.Embolism of air (choice A) has variable effects, although small amounts are typically inconsequential. Larger volumes (~ >100 mL) can obstruct arteries and lead to ischemia and necrosis; an air embolism that lodges in the right heart may lead to sudden death.However, air embolism is rare and is not the most likely event in this patient. Bone marrow embolism (choice B) can occur following a broken bone or cardiac resuscitation, but typically will have no clinical consequences.However, fat embolism (choice C) from a broken long bone or traumatized areas of adipose tissue can, when severe, produce clinical manifestations.

These follow the trauma by about 1–3 days and usually include dyspnea,skin rash, and acute neurologic changes. In a few cases this has been fatal. Venous thromboemboli from deep leg veins (choice E) could
not get past the lungs (with the unusual exception of paradoxical embolism in a person with a septal defect) so could not reach the kidneys or brain to cause the effects reported for this patient.

Twelve types of medical students

types of medical students
types of medical students
types of medical students
types of medical students
types of medical students
types of medical students
types of medical students
types of medical students
types of medical students
types of medical students
types of medical students
types of medical students

Friday, January 28, 2011

How to differentiate Seasonal and Swine flu, common cold and allergies with their possible management

seasonal flu, swine flue,allegies
With flu season in full swing, it’s important to know what ails you (so you can help stop the spread by staying home). But how do you really know if you have the flu—swine or seasonal—or if it’s just another cold or an allergy? Use our handy sympt-o-meter.

1. Seasonal flu:
Key symptom:
Fever that comes on fast
Best fix:
Acetaminophen or ibuprofen

If your fever hits 101°F or 102°F and comes with chest discomfort plus major aches and exhaustion, it’s probably the seasonal flu, says Neil Schachter MD, author of The Good Doctor’s Guide to Colds and Flu. Take pain pills for fever and aches, rest, and drink lots of liquids. Those at high risk—pregnant, elderly, or chronically ill—may need antiviral meds such as Tamiflu or Relenza.

2. Swine flu or H1N1:

Key symptoms:
Fever plus nausea, diarrhea, and vomiting

Best fix:
Acetaminophen or ibuprofen

The H1N1 virus feels a lot like seasonal flu (although possibly milder), but often comes with gastro issues, which make it even easier to get dehydrated. Drink plenty of fluids, and follow standard flu treatment. Stay home (this flu is highly contagious), and call your doc if you’re in the high risk category or if you’re not better after a week. Any flu can develop into pneumonia.

3. Colds:

Key symptom:
Nasal congestion

Best fix:
Rest, drink a lot of water

If you have a runny nose, a little cough, maybe a low-grade fever (below 100°F)—it’s probably a winter cold, which isn’t associated with body aches or high fever like the flu. Staying hydrated will boost your immune system and help relieve congestion. Cold medicine? It might help you feel better, but it won’t cure you any sooner. Plus, it might lead to side effects like dry mouth or sleep trouble.

4. Allergies:

Key symptom:
Itchiness (eyes, nose, and throat)

Best fix:
Antihistamines or a neti pot

Allergies are less troublesome in winter than spring and fall, but if you’re sneezy, itchy, and runny, you may be having an attack. It’s smart to keep on hand the allergy meds that work best for you, no matter the season. If you have chronic irritation, try a neti pot, a teapot-like tool that irrigates your sinuses and removes offenders, or a saline nasal spray.

Plan your acticities by using iStudiez application for iphone

iStudiez application for iphone

If you're a medical student, you may want to think about using iStudiez Pro as you study for your exams. This is a great tool that can help you leverage mobile technology as you're going through medical school. iStudiez can help you organize your schedule, keep up with homework and assignments, and stay on top of your grades. If you're on a tight budget, then you can get iStudiez Lite for free.

Once you start using the app you will immediately want nothing else to be the tool to arrange all your schedule and homework once and for good. Read below and find out why iStudiez Pro would be the most efficient app on your device!

ORGANIZING YOUR SCHEDULE
:
Unique built-in planner lets you input and easy manage all types of schedules including classic, alternating (A & B weeks), rotating and block schedule. Not only you can enter most common course details, but also add instructors with all related information such as office hours, affiliation, phone number and email address. As well you are welcome to add holiday periods and even cancel separate classes in case of outstanding events. In addition, you are supplied with an expanded set of icons designed especially for iStudiez Pro to mark your class types and extracurricular activities. Color labels are available for your convenience to mark each particular course.

FOLLOWING UP WITH YOUR HOMEWORK:
Special section is dedicated to keep track of your homework and assignments. Whatever is the way you are used to manage your tasks, you will find it all in iStudiez Pro. Either you want to organize your assignments by date, by course or by priority, or sort them into pending and completed, you have all options at your hand. Sometimes you might have group work, so it is envisaged that you can add a partner to any of your assignments (either choose from contacts or create a new contact right inside the app).

SUMMARIZING IT UP FOR YOU:
Once your schedule is added, the summary of current classes and tasks is automatically reflected in Today view. You'll see list of events and assignments including all details such as event type, location, time left, class instructor, number of tasks pending and what's next on schedule. Courses reflected in Today view are easily modifiable in each and every detail. Today icon always sticks you to the current date!

TRACKING YOUR GRADE/GPA
:
This option is based on assignments (support of weighted/non-weighted assignments), and GPA calculator is available both for current and past semesters. Support of most world used grading scales (letter grades, percents, points).

KEEPING YOU ALERT:
You will always be up to date with pending tasks and upcoming classes and events with iStudiez Pro. The app boasts Push Notifications feature which allows you set general alarm time for your classes and separate alarms for each of your assignments and homework. Setting the alarms is quick and smartly integrated within the interface of the app, so prepare to be the most resulting fellow ever with no special memorizing efforts!

GUARDING YOUR DATA
:
No way you will ever lose your data if something's wrong with your device. iStudiez Pro takes care of you and offers the option to back up your data by sending it to your e-mail address with tapping just one button!

Download from itunes now

Thursday, January 27, 2011

Breast Cancer Risk Factors, Diagnosis and treatment


BREAST CANCER

Risk Factors:
  • Age >50
  • Family History
  • LCIS or atypical hyperplasia
  • Dense breast tissue
  • BRCA mutation
Types:
  • Invasive
  • Ductal
  • Lobular
  • Mucinous
  • Tubular
  • Non-invasive
  • DCIS (does not metastasize)
Diagnosis;
  • Mammogram is a SCREENING TOOL
  • FNA
  • Excisional Bx
  • Core BxSterotactic BX
Who to MRI;
  • Known BRCA mutation
  • First degree relative with BRCA mutation
  • 20% risk based on validated model (BRACA-Pro)
  • Other familial syndrome
  • Cowden, Li-Fraummeni, HNPCC
  • Hx of chest wall RT btwn 10-30yr of age
  • e.g. Hodgkins disease
Treatment:
  • Surgical Treatment
  • Mastectomy
  • Breast conversation
  • Lumpectomy with XRT
Hormonal Treatment:
  • ER, PR, Her 2 nu status
  • Adjunct therapy to minimize risk of recurrence
  • Tamoxifen
  • Aromatase inhibitor (Irimidex)
  • Herceptin
Survival -/+ adjuvant tx:
T1a: 95% 96%
T1b: 90% 93%
T1c: 80% 86.5%
T2aN0: 70% 80%
T2bN1: 60% 73%
T3aN0: 70% 80%
T3bN1: 40% 60%
TXNXM1: <5% style="font-weight: bold;" size="4">Tamoxifen:
5 yrs duration (newer data to support 10)
Decreases recurrence risk by 37-54%
Increases overall survival by 11-34%
Monitor for development of endometrial cancer

What is Shock? Its epidemiology, clinical presentation, evaluation and management

Outline:
  1. Definition
  2. Epidemiology
  3. Physiology
  4. Classes of Shock
  5. Clinical Presentation
  6. Management
  7. Controversies
Definition;
A physiologic state characterized by Inadequate tissue perfusion, Clinically manifested by
  • Hemodynamic disturbances
  • Organ dysfunction
Epidemiology:
  • Mortality
  • Septic shock – 35-40% (1 month mortality)
  • Cardiogenic shock – 60-90%
  • Hypovolemic shock – variable/mechanism
Pathophysiology:
  • Imbalance in oxygen supply and demand
  • Conversion from aerobic to anaerobic metabolism
  • Appropriate and inappropriate metabolic and physiologic responses
Cellular physiology:
  • Cell membrane ion pump dysfunction
  • Leakage of intracellular contents into the extracellular space
  • Intracellular pH dysregulation
Resultant systemic physiology;
  • Cell death and end organ dysfunction
  • MSOF and death
Characterized by three stages:
  1. Preshock (warm shock, compensated shock)
  2. Shock
  3. End organ dysfunction

Compensated shock:
  • Low preload shock – tachycardia, vasoconstriction, mildly decreased BP
  • Low afterload (distributive) shock – peripheral vasodilation, hyperdynamic state
Shock:
  • Initial signs of end organ dysfunction
  • Tachycardia
  • Tachypnea
  • Metabolic acidosis
  • Oliguria
  • Cool and clammy skin
End Organ Dysfunction:
  • Progressive irreversible dysfunction
  • Oliguria or anuria
  • Progressive acidosis and decreased CO
  • Agitation, obtundation, and coma
  • Patient death

Classification of Shock:
Major classes of shock
  1. Hypovolemic
  2. Cardiogenic
  3. Distributive
Hypovolemic Shock:
  • Results from decreased preload
Etiologic classes:
Hemorrhage - e.g. trauma, GI bleed, ruptured aneurysm
Fluid loss - e.g. diarrhea, vomiting, burns, third spacing, iatrogenic
Hemorrhagic Shock

Cardiogenic Shock
:
  • Results from pump failure
  • Decreased systolic function
  • Resultant decreased cardiac output
Etiologic categories
Myopathic
Arrhythmic
Mechanical
Extracardiac (obstructive)

Distributive Shock;
  • Results from a severe decrease in SVR
  • Vasodilation reduces afterload
  • May be associated with increased CO
Etiologic categories:
Sepsis
Neurogenic / spinal

Other causes
Systemic inflammation – pancreatitis, burns
Toxic shock syndrome
Anaphylaxis and anaphylactoid reactions
Toxin reactions – drugs, transfusions
Addisonian crisis
Myxedema coma

Septic Shock;

Clinical Presentation
Clinical presentation varies with type and cause, but there are features in common
  • Hypotension
  • Cool, clammy skin (exceptions – early distributive, terminal shock)
  • Oliguria
  • Change in mental status
  • Metabolic acidosis
Evaluation
  • Done in parallel with treatment!
  • H&P – helpful to distinguish type of shock
  • Full laboratory evaluation (including H&H, cardiac enzymes, ABG)
  • Basic studies – CxR, EKG, UA
  • Basic monitoring – VS, UOP, CVP, A-line
  • Imaging if appropriate – FAST, CT
  • Echo vs. PA catheterization
  • CO, PAS/PAD/PAW, SVR, SvO2
Treatment:
  • Manage the emergency
  • Determine the underlying cause
  • Definitive management or support
Manage the Emergency
Your patient is in extremis – tachycardic, hypotensive, obtunded
How long do you have to manage this?
Suggests that many things must be done at once
Draw in ancillary staff for support!
What must be done?
One person runs the code!
Control airway and breathing
Maximize oxygen delivery
Place lines, tubes, and monitors
Get and run IVF on a pressure bag
Get and run blood (if appropriate)
Get and hang pressors
Call your senior/fellow/attending

Determine the Cause
Often obvious based on history
Trauma most often hypovolemic (hemorrhagic)
Postoperative most often hypovolemic (hemorrhagic or third spacing)
Debilitated hospitalized pts most often septic
Must evaluate all pts for risk factors for MI and consider cardiogenic
Consider distributive (spinal) shock in trauma
What if you’re wrong?

Definitive Management
Hypovolemic – Fluid resuscitate (blood or crystalloid) and control ongoing loss
Cardiogenic - Restore blood pressure (chemical and mechanical) and prevent ongoing cardiac death
Distributive – Fluid resuscitate, pressors for maintenance, immediate abx/surgical control for infection, steroids for adrenocortical insufficiency

What is Low Latent Inhibition? Find out its Pros, Cons and diagnosis

Low latent inhibition

Michael Scofield is the main protagonist in the American television series Prison Break. In this series, Michael was diagnosed to be suffering from LOW LATENT INHIBITION. It is here, i got an idea to right a post about LLI.

The brains of creative people appear to be more open to incoming stimuli from the surrounding environment. Other people's brains might shut out this same information through a process called "latent inhibition" - defined as an animal's unconscious capacity to ignore stimuli that experience has shown are irrelevant to its needs. Through psychological testing, the researchers showed that creative individuals are much more likely to have low levels of latent inhibition.

This means that creative individuals remain in contact with the extra information constantly streaming in from the environment. The normal person classifies an object, and then forgets about it, even though that object is much more complex and interesting than he or she thinks. The creative person, by contrast, is always open to new possibilities.

As you grow, the mind learns to label objects and filter out extraneous information.This filtering process is called 'latent inhibition' - and it means that the conscious mind is only aware of a fraction of the data being processed by the brain. In some rare cases, the ability to filter incoming data is decreased. People with LLI (low latent inhibition) are incapable of seeing things in terms of labels. They notice an awful lot more. Reality becomes more vivid and alive. Everyone has different levels of latent inhibition. It can become a problem if the inhibition process is radically decreased. LLI is not a disease. You do not suffer from it. It is a dysfunction that has both positive and negative sides.

For most people, reality is experienced piecemeal. They concentrate on one task at the exclusion of other things. Whilst typing on the computer, hearing diminishes, smell diminishes - the awareness is narrowed. With LLI this is not the case at all. The input is constant. Your awareness does not fluctuate. It only oscillates between hyper-awareness and extreme-awareness - with the latter being something to be concerned about. LLI puts you in touch with the raw immediacy of reality. The overwhelming sensory input means that you experience everything simultaneously: the humming of the computer, the flickering of the monitor, the feel of the clothing you wear, your emotions, the bird in your garden, the smell of coffee... Every miniscule detail happening around you is felt in its entirety. This does not mean that you read every word, remember every facet, but you do see it, smell it, hear it, taste it and feel it. The information is absorbed. Your mind is sponge-like in its capacity to pick things up. You learn from them, and demonstrate new insights and understanding.

Pros-
  • You notice more, hear more, smell more and feel more through tactile contact. Without any conscious effort, your mind is in possession of a broader intake of information.
  • Upon encountering any form of stimulus (that interests you), your mind automatically dismantles and explores its components.
  • You usually see through the lies and the deceptions that people use in everyday life.
  • When learning, you can often make instantaneous changes.
  • Self-correction is easy because the underlying principle is more evident. Clearer.
  • You make connections and associations between seemingly unrelated material.
  • Comprehension is typically easy. You notice the non-verbal background information and this often provides a more comprehensive picture than what is being spoken.
  • There are exponential leaps of insight taking place all the time, with the background reasoning intact. Wave-upon-wave of permutations, options, variables and choices.
  • Creativity is a given. You see alternatives.
  • You notice things that other people miss.
  • There is no talking voice in your head. No 'chattering monkey'. The volume and complexity of the information drowns out conscious thought entirely.
  • Verbalising what takes place in your mind is impossible. Words render only a fraction of the entirety.
  • You see the world more thoroughly.
  • Listening to other people talking/thinking aloud can be infuriating. They are at point A when you have reached point N already.
  • Learning is not limited to defined periods of academic study. The assimilation of information is constant, ongoing and never static. There are no lulls or pauses. Everything offers a lesson.
  • Within the maelstrom of information there exists a place of calm and quietude. The eye of the storm. No verbalisation exists. No internal narrative. Just presence. No sense of self to intrude of interrupt.
Cons-
  • Education is awkward. Schools are not set-up to cater with this disorder. The way in which things are approached by schools seems piecemeal and incomplete.
  • It is difficult to write/type/speak quickly enough to articulate ideas and the breadth of the permutations involved.
  • Tact is necessary. People lie constantly.
  • LLI makes driving a car difficult. Your brain notices countless dangers and variables, and you become overwhelmed and nervous.
  • Hypervigilance can lead to anxiety.
  • Illusions are not very effective. You see through things without wanting to. Conventions and traditions have no significance.
  • You do not value what other people value.
  • Filtering out the variables and honing your options to something workable can be very difficult. Every solution potentially harbours new problems, new variables and new concerns.
  • People may find you to be a little odd, unorthodox or a little intense.
  • You have a habit of saying things that do not fit the accepted norm of behaviour. You often choose to disregard conventions because they serve no constructive purpose.
  • Background noise is a major problem. Noisy neighbours can cause serious stress.
  • Noticing things does not mean that you understand them. If anything, the abundance of what might be known lessens the desire to accumulate widespread knowledge.

AWARENESS:
A person experiencing LLI is not initially aware that they have the condition. To them, how they regard the world seems perfectly normal. Nothing unusual is apparent - they do not know anything else. The condition may become apparent through the differences in what you say and see, relative to other people. In many cases the condition remains undiagnosed.

DO YOU HAVE LLI?
If you believe you have LLI, you probably don't. It is hard to self-diagnose yourself because individuals with LLI don't know any different than what they see every day. They believe everyone sees what they see.

Wednesday, January 26, 2011

Central Heating Linked to making you fat: Sitting in your cosy home stops you from burning calories


Having the heating on high could also pile extra pounds on your weight, scientists believe. Experts say many of us now keep our homes so cosy that we no longer have to burn as many calories to naturally warm up our bodies. Modern centrally heated homes with efficient double glazing are helping to send obesity rates soaring, a study claims.

Scientists from University College London say it is an increasing problem across the developed world where average indoor temperatures are constantly rising. And its impact on weight is made worse by the extra time we now spend indoors, whether working from home or shopping online.

Even when we do venture out, it is often via heated cars or other transport to offices and workplaces where the temperature is carefully controlled by air conditioning units. The research, in the journal Obesity Reviews, said there was a direct link between ‘reduced exposure to seasonal cold and increases in obesity in the UK and U.S.’

If the body is already warm it does not need to convert a ‘brown’ fat known as adipose ­tissue into energy to generate heat, the study said. Brown fat was previously thought to be present only in infants, playing a vital role in keeping them warm, but recent research found it also in adults.

This latest study suggested that prolonged exposure to comfortable warm temperatures may permanently reduce the body’s ability to burn this brown fat. Increased time spent indoors, widespread access to central heating and air conditioning, and increased expectations of thermal comfort all contribute to restricting the range of temperatures we experience in daily life. This reduces the time our bodies spend under mild thermal stress – meaning we’re burning less energy. This could have an impact on energy balance and ultimately have an impact on body weight and obesity.

Tuesday, January 25, 2011

Children who have low levels of self-control at three are more likely to have a Criminal Record by the age of 32



It's worrying news for any parent who's struggled with a headstrong young child. Scientists claim that children who have low levels of self-control at three are more likely to have health and money problems and a criminal record by the age of 32, regardless of background and IQ.

Researchers from Britain, the U.S. and New Zealand analysed data from two large studies in which children completed a range of physical tests and interviews to assess genetic and environmental factors that can shape their lives. They found that children with low self-control were more likely to have health problems in later life including high blood pressure, being overweight, breathing problems and sexually transmitted infections.

They were also more likely to be dependent on substances such as tobacco, alcohol and drugs, more likely to be single parents, have difficulty managing money and have criminal records. Willpower of a child really does influence your chances of a healthy and wealthy adulthood.

The researchers firstly looked at data from around 1,000 children born in New Zealand between April 1972 and March 1973. The participants' self-control was assessed by teachers, parents, observers and the children themselves and included things like having low frustration tolerance, lacking persistence in reaching goals, being over-active and acting before thinking.

When the participants reached their early 30s, this impulsivity and relative inability to think about the long-term gave them more problems with finances, including savings, owning a home and credit card debt. The children with lower self-control scores also scored highest for things like sexually transmitted diseases, weight problems, having high cholesterol and high blood pressure.

To corroborate the findings, the researchers ran the same analysis on data from 500 pairs of fraternal twins in Britain. They found that the sibling with lower self-control scores at age five was more likely to start smoking, do badly at school and engage in anti-social behaviour at age 12. This shows that self-control is important by itself, apart from all other factors that siblings share, such as their parents and home life.

Acute Abdomen, its sign symptoms, History, Examination and Treatment


INTRODUCTION;
Acute abdomen is the most common presenting surgical emergency. It has been estimated that at least 50% of general surgical admissions are emergencies and 50% of them present with acute abdominal pain.

Studies have shown a 30-day mortality of 4% among patients admitted with acute abdomen. So, it represents a significant part of the general surgical workload. The aim is to differentiate serious causes from less serious causes of acute abdominal pain. The acute abdomen may be defined generally as an intra-abdominal process causing severe pain requiring admission to hospital, and which has not been previously investigated or treated and may need surgical intervention. The mortality rate varies with age, being the highest at the extremes of age. The highest mortality rates are associated with laparotomy for unresectable cancer, ruptured abdominal aortic aneurysm and perforated peptic ulcer. Most common causes in any population will vary according to age, sex and race, as well as genetic and environmental factors.

Causes:


A. Gastrointestinal-

1-Gut
Acute appendicitis
Intestinal obstruction
Perforated peptic ulcer
Diverticulitis
Inflammatory bowel disease
Acute exacerbation of peptic ulcer
Gastroenteritis
Mesensteric adenitis
Meckel’s diverticulitis

2-Liver and biliary tract
cholecystitis
cholangitis
Hepatitis
biliary colic

3-Pancreas
Acute pancreatitis

4-Spleen
Splenic infarct and spontaneous rupture

B. Urinary tract:
Cystitis
Acute pyelonephritis
Ureteric colic
Acute retention

C. Vascular:
Ruptured aortic aneurysm
Mesenteric embolus
Mesenteric venous thrombosis
Ischemic colitis
Acute aortic dissection

D. Abdominal wall conditions:
Rectus sheath haematoma

E. Peritoneum:
Primary peritonitis
Secondary peritonitis

F. Retroperitoneal;
Hemorrhage e.g anticoagulants


G. Gynecological;
Torsion of ovarian cyst
Ruptured ovarian cyst
Fibroid denegeration
Ovarian infarction
Salpingitis
Pelvic endometriosis
Severe dysmenorrhea
Endometriosis


H. Extra-abdominal causes;
Lobar pneumonia
Pleurisy
MI
Sickle cell crisis
Uremia
Hypercalcemia
DKA
Addison’s disease
Acute intermitent porphyria

Classification with age:
  • Children
Gastroenteritis
Mesentric adenitis
Meckel’s diverticulitis
Intussusception
Henoch-schonlein purpura

  • Adult
Regional enteritis
Ureteric colic
Perforated ulcer
Testicular torsion
Pancreatitis

Relation of pain to embryology:
• Intestine and its outgrowths (the liver, biliary system and pancreas)-> midline.
• Irritation of foregut structures
• (oesophagus to the second part of the duodenum)
• ->epigastric area.

• Midgut structures
• (the second part of the duodenum to the splenic
• flexure) ->umbilicus.

• Hindgut structures (the splenic flexure to the rectum)->
• hypogastrium.

Management:
• History
• Physical examination
• Management

• History-
– Biodata
Age:
• Mesenteric adenitis in children
• Diverticulitis in elderly
Gender

Characteristics of abdominal pain

• Site
• Time and mode of onset
• Severity
• Nature/Character
• Progression
• Radiation
• Duration
• Cessation
• Exacerbating/relieving factors
• Associated symptoms
Site-pain

Whole abdomen
Peritonitis or mesentric infarction

Right upper quadrant
Acute cholycystitis
Cholangitis
Hepatitis
Peptic ulceration

Left upper quadrant
Peptic ulceration
Pancreatitis
Splenic infarct


Right lower quadrant
Appendicitis
Ovarian cyst Ectopic pregnancy PID Right ureteric colic

Left lower quadrant
Sigmoid diverticular disease
Ovarian cyst
Ectopic pregnancy
PID
Left ureteric colic

Symptoms--Pain

Onset
sudden: perforation of bowel, smooth muscle colic
slow insidious onset: inflammation of visceral peritoneum

Severity
Patient asked to rate pain from 1-10
Ureteric colic is one of worst pains

Character
Aching-dull pain poorly localised
Burning- peptic ulcer symptoms
Stabbing-ureteric colic
Gripping-smooth muscle spasm e.g. intestinal obstruction worse by movement ; wringing of cloth

Progression
-Constant e.g. peptic ulcer
-Colicky e.g. seconds(bowel), minutes(ureteric colic) or tens of minutes (gallbladder
-may change character completely from dull poorly localized pain to sharp pain indicates involvement of parietal peritoneum e.g.appendicitis

Radiation of the pain
Back: duodenal ulcer, pancreatitis, aortic aneurysm
Scapula: gall bladder
Sacroiliac region: ovary
Loin to groin: ureteric colic
Groin: testicular torsion


Cessation-
abrupt ending- colicky pains
resolving slowly-inflammatory pain, biliary pain

Exacerbating/relieving factors-
Movement/Rest-inflammatory conditions
Food- peptic ulcers


Past history
previous surgery
trauma
any medical diseases

Drug history
corticosteroid: mask pain
anti-coagulant: intra-mural hematoma
NSAIDS: gastritis, peptic ulcer

Family history
colon cancer
IBD

Intestinal obstruction:
• One of the common cause of acute abdomen
• May lead to high morbidity and mortality if not treated correctly
It can be classified into two types:
  1. Dynamic (mechanical)
  2. Adynamic
Dynamic;

1.Intraluminal: impacted faeces, foreign bodies, gallstones

2.Intramural: tumours, inflammatory strictures, congenital atresia

3.Extramural: adhesion, hernias, volvulus, intussusception, tumours

It can also be divided into:
1. Small bowel obstruction (SBO)
-high ->early perfuse vomiting
rapid dehydration
-low->predominant pain, and central distention
Vomiting delayed
air-fluid levels seen on AXR

2. Large bowel obstruction (LBO)
early pronounced distension, mild pain
vomiting, dehydration late
e.g. -carcinoma
-diverticulitis or volvulus

Adynamic;

1.Paralytic ileus (peristalsis is absent)

2.Peristalsis is present in a non-propulsive form e.g. mesentric vascular occlusion

Obstruction can be-

Simple: blockage without interfering with vascular supply

Strangulation: significant impairment of blood supply most commonly associated with hernia, volvulus, intussusception and vascular occlusion
-surgical emergency

Closed loop obstruction: bowel is obstructed at both the proximal and distal end)

Pathophysiology;

Irrespective of etiology or acuteness of onset:

Proximal to obstruction
Increased fluid secretion ? abdominal distention
Accumulation of gas ? abdominal distention
Increased intraluminal pressure
Decreased reabsorption with time and flaccidity to prevent vascular damage from high pressure
Vomiting
Dehydration
Dilatation of bowel
Reflex contraction of smooth muscle ? colicky pain
Increased peristalsis to overcome obstruction ? increased bowel sounds
If obstruction not overcome ? bowel atony

Distal to obstruction: nothing is passed & bowel collapse ? constipation


Symptoms:
The four cardinal features of intestinal obstruction:
-abdominal pain
-vomiting
-distension
-constipation

Vary according to:-
location of obstruction
age of obstruction
underlying pathology
intestinal ischemia

Abdominal pain
colicky in nature, around the umbilicus in SBO while in the lower abdomen in LBO
if it becomes continuous, think about perforation or strangulation
Vomiting
-starts early in SBO and late in LBO
-vomitus starts with clear color then becomes thick, brown and foul ( faeculent)
-more with lower or complete obstruction
-diarrhea may be present with partial obstruction
Distension
-more with lower obstruction

Constipation
-more with lower or complete obstruction
-diarrhea may be present with partial obstruction
-either absolute (no feces or flatus)<-cardinal in absolute IO or relative (flatus passed) Distension -more with lower obstruction In strangulation: • severe constant abdominal pain • distended abdomen • fever • tachycardia • tender abdomen

Clinical examination:


General examination-
Vital signs
Signs of dehydration –tachycardia, hypotension
dry mucus membrane, decreased skin turgor, decreased urine output

Inspection
distension, scars, peristalsis, masses, hernial orifices

Palpation
tenderness, masses, rigidity

Percussion tympanitic abdomen

Auscultation
high pitched bowel sound or silent abdomen

*Examine rectum for mass, blood, feces or it may be empty in case of complete obstruction


Investigations
• CBC- WBC (neutrophilia-strangulation)
• Hb
• U&E
• Plain AXR
• Sigmoidoscopy (carcinoma, volvulus)
• Double Contrast x-ray ( complete or incomplete)
• CT abdomen
Normal Gas Pattern
AXR
Stomach
Always
Small Bowel
Two or three loops of non-distended bowel
Normal diameter = 2.5 cm
Large Bowel
In rectum or sigmoid – almost always

Normal Fluid Levels
Stomach
Always (except supine film)
Small Bowel
Two or three levels possible
Large Bowel
None normally

Treatment;
• Three main measures-
- GI drainage
- F&E replacement
- Relief of obstruction, usually surgical

• Some cases will settle by using this conservative regimen, other need surgical intervention.

• Surgery should be delayed till resuscitation is complete unless signs of strangulation and evidence of acute or closed-loop obstruction.

• Cases that show reasons for delay should be monitored continuously for 72 hours in hope of spontaneous resolution e.g. adhesions with radiological findings but no pain or tenderness

• “The sun should not both rise and set” in cases of unrelieved obstruction.

Indication for surgery:

- failure of conservative management
- tender, irreducible hernia
-strangulation

Type of surgery depends upon the nature of the cause.
Laprotomy is usually done.
Decompression of obstruction ( by repair of hernia, complete lysis of adhesion).


Surgical treatment
;

Once obstruction relieved, the bowel is inspected for viability, and if non-viable, resection is required.

Indication of non-viability
1.absent peristalsis
2.loss of normal shine
3.loss of pulsation in mesentry
3.green or black color of bowel

• If in doubt of viability, bowel is wrapped in hot packs for 10 minutes with increased oxygen and reassessed for viability.
• Sometimes a second look laprotomy is required in 24-48 hours e.g. multiple ischemic areas.
• Right sided large bowel lesion is treated by right hemicolectomy with covering colostomy

Holy ZAMZAM water is 1000 times better than other water and Nothing is Negative about it

Monday, January 24, 2011

Assessment, Resuscitation and treatment of Burn Injuries




I. Assessing Severity of Burn Injury
A. Functions of the Skin:
1. maintains fluid and electrolyte balance
2. protects the body from invasion
3. regulates body temperature

B. Anatomy:
1. epidermis
2. dermis (includes epidermal appendages)
3. subcutaneous tissue
4. fascia and muscle


C. Assessment of Burn Depth – related to temperature, time of exposure, and thickness of skin:
1. First degree burn
a. caused by sunburn or flash
b. involves epidermal layer only
c. usually appears red to pink
d. is painful to touch
e. may become slightly edematous
f. heals in 3-5 days (rarely leaves any scar)
g. does NOT count in the burn size calculation

2. Second degree burn (partial-thickness)
a. usually caused by flash, scalds, or brief contact with hot object
b. involves the epidermis and part of the dermis
c. has vesicles and bullae
d. moist appearance – usually red to pale pink
e. tactile and pain sensibility is intact – very painful
f. develops significant edema
g. heals in 7-21+ days with variable amounts of scarring

3. Third degree burn (full-thickness)
a. usually caused by flame, high intensity flash, electricity, chemicals, or prolonged contact with hot liquids or hot objects
b. extends through the epidermis and dermis
c. usually appears white, brown or black; may have thrombosed veins
d. wound appears dry
e. elasticity of the wound is destroyed, so wound becomes leathery and feels firm to the touch
f. marked edema and decreased elasticity may necessitate escharotomies
g. generally painless to touch

4. Escharotomies
a. longitudinal incisions through eschar that release constriction
b. may be necessary in presence of full-thickness circumferential burns of an extremity or chest.
c. assess adequacy of circulation (pulse, capillary refill, movement, numbness, tingling, pain) and elevate

5. Zones of injury
a. zone of coagulation
b. zone of stasis
c. zone of hyperemia

D. Estimation of Burn Size -- calculating per cent Total Body Surface Area burned (%TBSA):
1. Rule of Nines
Adults Infants
head and neck 9% 18%
each upper extremity 9% 9%
anterior trunk 18% 18%
posterior trunk 18% 18%
each lower extremity 18% 14%
perineum 1% 1%
100% 100%

2. Lund and Browder Chart (see attached)
3. Rule of the Palm
a. the patient’s anterior hand is approximately 1% of his body surface area
b. useful in estimating burn size of splash-injuries or small burns


E. Burns of Special Areas
:
1. face, ears
2. hands
3. feet
4. joints
5. perineum


II. Care of Some Special Types of Injuries:
A. Tar, wax
B. Chemical injuries
1. pathophysiology
2. treatment
3. chemical burns to the eyes


C. Electrical injuries
1. pathophysiology
2. problems associated with electrical injuries
a. types of wounds
- contact points (entry and exit)
- arc wounds
- flame burns
b. cardiac
c. pulmonary
d. gastrointestinal
e. renal
f. neurologic
g. musculoskeletal
3. sequelae of electrical injuries

D. Burns associated with Child Abuse
1. history requiring closer evaluation
2. appearance of suspicious burns
3. documentation required


III. Smoke Inhalation:
A. Carbon Monoxide poisoning (kills during and immediately following the fire)
1. CO from the fire combines with the circulating hemoglobin, bumping the oxygen from its receptor sites
2. signs of CO poisoning include confusion, dizziness, headache, nausea
3. treatment: administration of 100% oxygen

B. Upper airway obstruction
1. burns of the face, mouth, tongue, pharynx results in massive edema formation and the potential for airway obstruction
2. edema continues to develop for up to about 24 hours
3. treatment: intubate to mechanically maintain airway patency
4. edema will usually decrease at about post-burn day #3, and the patient may then be able to be extubated

C. Pulmonary injury from the chemicals inhaled
1. patient develops ARDS over the first 24 hours post-injury
2. pneumonia may also occur (sometimes as late as 10 days post-burn)


IV. Fluid Resuscitation:
A. Pathophysiology of “Burn Shock”
1. fluid shifts
2. decreased cardiac output
3. electrolyte and hematologic alterations
4. renal effects
5. central nervous system effects
6. compensation for “burn shock”
a. effects on skin
b. effects on gut

B. Fluid Resuscitation (in the first 24 hours post-burn)
1. Baxter (or Parkland) formula:
(4ml of Ringers Lactate) x (% burn) x (kg weight) = mls required in first 24 hrs

½ is given in the first 8 hours (calculated from time patient was burned)
¼ is given in the second 8 hours
¼ is given in the third 8 hours

EXAMPLE: 4 ml / 70 kg / 50% TBSA = 14,000 ml fluid resuscitation required
(7 liters given in first 8 hours)

2. IV access guidelines:
a. <> 45% TBSA: secure 2 large bore IV lines in upper extremities

3. Pediatrics (children 0-3 years) – add maintenance fluids as D5¼ NS to Baxter formula

4. Evaluation of adequacy of fluid resuscitation
a. alert sensorium
b. adequate urine output (>30 ml/hr in adult; 1 ml/kg/hr in children up to 30 kg)
c. slightly high normal pulse, usually about 100
d. normal blood pressure for age
e. relief of paralytic ileus or nausea


V. Initial Treatment
:

A. History for initial assessment
1. type of burn
2. history of flame burns / closed-space accident?
3. circumstances surrounding the injury (LOC, seizure, fall, crash, blast)
4. pre-existing diseases and medications
5. first aid measures already taken


B. Emergent Care
1. maintain an adequate airway and begin oxygen
2. assess for associated life-threatening injuries
3. initiate fluid therapy
4. insert foley catheter to monitor hourly urine output (burns >25% TBSA)
5. insert nasogastric tube (burns > 20% if air transport is planned)
6. keep patient warm (!)
7. elevate burned extremities; monitor pulses
8. tetanus prophylaxis
9. pain management (small IV doses only)
10. psychological support of patient and family

C. Advanced Burn Life Support Burn Center Referral Criteria:
1. full-thickness (3rd degree) burns
2. partial-thickness (2nd degree) burns >10% TBSA
3. burns of special areas
a. face, hands, feet, genitalia, or across major joints
b. circumferential full-thickness burns of an extremity or trunk
4. electrical injuries
5. chemical injuries
6. patients with inhalation injury in addition to burns
7. patients with pre-existing disease
8. patients with concomitant trauma

Transport
Wrap patient in dry sheet and blanket for transfer (sterile if you have it; clean if you don’t)
No ice or (cold) soaks
Don’t apply topical antibiotics before transport, unless transfer is delayed.


VI. Wound Care:
A. Initial wound care
1. isolation: scrubs or gown, mask, gloves
2. cleanse wounds; blisters are usually debrided if patient will be admitted
3. shave as needed; never shave eyebrows
4. topical agents as ordered (not usually necessary at referring hospital)

B. Daily wound care
1. pain medication is needed prior to dressing changes
2. dressings may usually be soaked off
3. remove any old cream and gently wash wounds
4. debride any loose tissue
5. reapply topicals and dressings as ordered

C. Assess daily for signs of infection
1. cellulitis (redness, heat, swelling)
2. darkening of the eschar
3. odor
4. purulence or greenish drainage
5. deterioration of a healing wound

D. Assess for early signs of sepsis
1. disorientation
2. decreased urine output
3. metabolic acidosis
4. tachypnea
5. tachycardia
6. paralytic ileus or vomiting
7. hyperglycemia
8. hyper- or hypo-thermia

E. Debridement
1. if you can get between dead and viable tissue, the dead tissue should be removed
2. mechanical debridement by nurses should not cause bleeding
3. some debris will come off with coarse mesh gauze dressing changes
4. most patients are not debrided under general anesthesia in the OR
a. tangential excision – shave layer by layer until a bleeding (viable) bed is produced (to maximize tissue salvage)
b. primary or fascial excision – separate tissue at fascial layer to minimize blood loss

F. Topical Antibiotics
1. Silver sulfadiazine (Silvadene, Flamazine, Thermazine, SSD)
a. a water-soluble cream which is locally non-toxic
b. bactericidal spectrum against a wide range of gram+ and gram- organisms and candida albicans
c. pain-free application
d. softens the eschar; may combine with exudate to form a gelatinous layer
e. few side effects: is generally applied once daily

2. Mafenide acetate (Sulfamylon)
a. a water soluble cream or, or a powder that may be mixed with saline
b. bacterial spectrum: gram+, gram – organisms, some anaerobes, but not yeast
c. hypersensitivity reactions (rashes) to sulfa are sometimes seen

3. Bacitracin and other petroleum ointments
a. “benign” topicals which mostly contain moisture
b. microbes may become resistant
c. typically used for scrapes and abrasions

4. Muperacin (Bactroban)
a. an ointment used against gram+ organisms
b. used when methacillin resistant staph aureus (MRSA) is found in wounds
c. should also be applied to nares, when used

5. Silver Nitrate (bulky wet dressings)
a. AgNO3 isn’t used much anymore because it stains everything black
b. A 0.5% solution of AgNO3 in water – keep dressings wet so that concentration of AgNO3 doesn’t increase (concentrated AgNO3 is caustic to wounds)
c. water-soaked dressings are uncomfortable and can leech electrolytes



6. Acticoat
a. a slow-release silver-impregnated dressing
b. silver is released by water (either from the wound or exogenously applied) for about 3 days
c. is being used on shallow wounds and donor sites to decrease dressing changes

G. Grafting

1. Xenograft or Heterograft (used as a biologic dressing)
a. animal skin (usually pig) which is used as a temporary wound coverage
b. is applied to a clean shallow wound, to protect it until it heals
c. dries and separates from the wound, as the wound heals underneath


2. Allograft or Homograft (used as a biologic dressing)
a. non-self human skin (usually cadaver) which is used as temporary wound cover
b. if left in place long enough (> 5 days) it will become vascularized, and will have to be excised in OR to remove it
c. if left in place long enough, patient may develop a rejection reaction to it
d. used to “buy time” and temporarily close a wound until patient’s own skin is available
e. used as a “test graft” to determine if a wound is ready to accept a skin graft


3. Autograft
a. skin taken from one area of the patient’s body to another
b. sheet graft
- whole graft is laid intact on wound
- used in cosmetic areas of the body (face, neck, hands)
- require meticulous care post-op to prevent fluid accumulation beneath it
c. meshed graft
- passed through a machine that creates slits in it – so it can be expanded
- is often wrapped, with no dressing changes, for first 3-5 days after application
d. donor site – area that gives up skin used in skin graft
- is often more painful than burn wounds
- may be covered with a dressing or topical; heals by epithelialization


4. Integra
a. is placed on a newly excised wound (after all dead tissue is removed)
b. becomes vascularized, forming a “neodermis” over about 3 weeks
c. is grafted with thin epidermal grafts after the new dermis develops


VII. Rehabilitation
:
A. Beings at the time of admission

B. Prevention of contractures
1. exercising
2. positioning
3. splinting to maintain stretch

C. Minimizing scarring
1. elasticized circular bandage initially
2. custom fitted pressure garments
3. may require silicone inserts

D. The nature of scars
1. can’t easily predict who will scar, but partial thickness wounds that heal over more than 3 weeks tend to scar the most
2. scars will become redder and firmer 6-8 weeks after the wound heals; then will begin to blanche out and soften over about a 1-year period
3. Scars may tingle, itch or burn as they mature

E. Other post-hospitalization issues
1. body-image changes
2. role changes
3. uncomfortable sensations in burns
4. changes in sweating pattern
5. fatigue
6. return to work / school
7. PTSD

F. Interventions
1. motivational strategies
2. reconstructive surgery
3. tissue expanders
4. make-up consultation
5. tattooing (for color match)
6. support groups


Sunday, January 23, 2011

Introduction to Hernia, its types, mechanism of development, signs, symptoms and treatment


OBJECTIVES:

  • What is meant by hernia
  • The mechanism of developing a hernia
  • Signs and symptoms produced by a hernia
  • The types of hernia
  • Complications produced as a result of hernia
  • Treatment of hernia
  • Preventive measures against development of hernia
DEFINITION:
A hernia is a protrusion of any viscus from its proper cavity. The protruded parts are generally contained in a sac-like structure, formed by the membrane with which the cavity is naturally lined.

MECHANISM:
The wall of the abdomen, the gastro-oesophageal valves, and other areas of the body, comprising muscle and tendon, performs several functions, one of which is to provide strong support to the internal organs which are exerting significant outward pressure. The opening of a gap in the tissue can occur of its own accord at a point of natural weakness, or by over-stretching a part of the tissue. Overexertion can cause a hernia eg, lifting heavy loads or chronic cough

TYPES OF HERNIA:

  • Groin hernia (inguinal, femoral, scrotal)
  • Umbilical
  • Incisional
  • Hiatal
  • Congenital diaphragmatic
  • Ventral / Epigastric Hernia
  • Spigelian Hernia
  • Recurrent Hernia
  • Stoma Hernia
  1. INGUINAL HERNIA:
A portion of intestine or internal fat protrudes through a weakness in the inguinal canal.
Appears at the groin crease.
May be DIRECT or INDIRECT.
More common in males.

2. FEMORAL HERNIA:
Hernia through the femoral canal in the femoral triangle.
Appears between the thigh and groin region.
More common in females.

3. UMBILICAL HERNIA:
Hernia in the abdominal wall from or around the umbilicus (paraumbilical)

4. INCISIONAL HERNIA:
From defects created due to previous surgeries

5. HIATAL HERNIA:
Stomach passes from the gastro oesophageal sphincter into the oesophagus

6. EPIGASTRIC:
From a defect between the umbilicus and xiphisternum in the midline

7. SPIGELIAN:
This rare hernia occurs along the edge of the rectus abdominus muscle, which is several inches to the side of the middle of the abdomen.

8. OBTURATOR HERNIA:
This hernia protrudes from the pelvic cavity through an opening in the pelvic bone (obturator foramen).
Causes no bulge
Difficult to diagnose

9. RECURRENT HERNIA:
Occurs at the site of previous hernia repair

10. CONGENITAL DIAPHRAGMATIC HERNIA:
A diaphragmatic hernia is a birth defect in which there is an abnormal opening in the diaphragm

11. STOMA HERNIA:
Occur at the site of surgical stoma

RISK FACTORS:

  • Family history
  • Overweight or Obesity
  • Undescended testes (groin hernias)
  • Gastro-oesophageal reflux disease (GERD)
  • Any condition that increases the abdominal pressure:e.g.,
– chronic coughing,
– chronic constipation
– enlarged prostate causing straining with urination,
– carrying or pushing heavy loads

SYMPTOMS
:
  • Lump
  • Painful swelling
  • Nausea/ vomiting
  • Sepsis
SIGNS:
  • Lump
– Reducible/ irreducible: can or cannot be pushed back to its original position
– Direct/ indirect (inguinal hernia): comes through the abdominal wall (direct) or through the inguinal canal (indirect)
– Tender
  • Fever
  • Signs of Intestinal obstruction
  • Sepsis

COMPLICATIONS:
  • Incarceration:
– Hernia contents get “stuck” in the hernia sac causing irreducibility
  • Obstruction:
– Intestinal obstruction as a result of incarceration

  • Strangulation:
– Blood circulation to the hernial contents is compromised
– Necrosis/ gangrene formation
– Sepsis


DIAGNOSIS:
  • Clinical, based on physical examination
  • U/S
  • C.T. scan
  • Fetal U/S for congenital defect

TREATMENT:

  1. CONSERVATIVE:
  2. DEFINITIVE:
Surgical repair

PREVENTION:
  • Few preventive measures
Avoid heavy weight lifting and straining
Avoid food that precipitate reflux from stomach into oesophagus (hiatal hernia)

Download Mayo Clinic Analgesic Pathway: Peripheral Nerve Blockade for Major Orthopedic Surgery, 1st ed. 2005 free

Mayo Clinic Analgesic Pathway: Peripheral Nerve Blockade for Major Orthopedic Surgery Robert L. Lennon and Terese T. HorlockerISBN-10: 0849395720 ISBN-13: 978-0849395727 Informa Healthcare



Resolving to expedite the recovery process, this reference describes a comprehensive multimodal approach to intraoperative regional anesthesia and postoperative analgesia in patients undergoing major lower extremity orthopedic surgery-spanning the entire selection of regional anesthesia equipment, strategies in pain management, and practical treatment guidelines for the management of inpatient and ambulatory peripheral nerve catheters. The authors' systematic approach to regional anesthesia and analgesia in patients undergoing total joint replacement has been recognized for its scientific and educational value by the American Academy of Orthopaedic Surgeons and the American Society of Anesthesiologists

This guide helps readers by:

offering prudent, practical management guidelines for optimal medical care
describing needle redirection cues for each block
illustrating anatomical landmarks for selecting the needle insertion site
supplying detailed medical illustrations of proper positioning for the patient and proceduralist


Histology and Explanation of Fibroadenoma of the breast



Fibroadenoma of the breast is a benign tumor composed of two elements : epithelium and stroma. It is nodular and encapsulated, included in breast. The epithelial proliferation appears in a single terminal ductal unit and describes duct-like spaces surrounded by a fibroblastic stroma. Depending on the proportion and the relationship between these two components, there are two main histological features : intracanalicular and pericanalicular. Often, both types are found in the same tumor. Intracanalicular fibroadenoma (photo A) : stromal proliferation predominates and compresses the ducts, which are irregular, reduced to slits. Pericanalicular fibroadenoma (photo B) : fibrous stroma proliferates around the ductal spaces, so that they remain round or oval, on cross section. The basement membrane is intact.