Histology and Explanation of Tuberculous Lymhadenitis

Tuberculous lymphadenitis is a chronic specific granulomatous inflammation with caseation necrosis. The characteristic morphological element is the tuberculous granuloma (caseating tubercule) : giant multinucleated cells (Langhans cells), surrounded by epithelioid cells aggregates, T cell lymphocytes and few fibroblasts. Granulomatous tubercules evolve to central caseous necrosis and tend to become confluent, replacing the lymphoid tissue.