Perepheral Neuropathy Frequently Asked Questions

A few causes of thickened nerves?
· Amyloidosis.
· Charcot-Marie-Tooth disease.
· Leprosy.
· Refsum's disease (retinitis pigmentosa, deafness and cerebellar damage).
· D5j5rine-Sottas disease (hypertrophic peripheral neuropathy).

What are the causes of motor neuropathy?
· Guillain-Barrd syndrome.
· Peroneal muscular atrophy.
· Lead toxicity.
· Porphyria.
· Dapsone toxicity.
· Organophosphorous poisoning.

What are the causes of mononeuritis multiplex?
Mononeuritis multiplex is a neuropathy affecting several nerves; causes include:

· Wegener's granulomatosis.
· Amyloidosis.
· Rheumatoid arthritis.
· Diabetes mellitus.
· SLE.
· Polyarteritis nodosa.
· Leprosy.
· Carcinomatosis, Churg-Strauss syndrome. (Mnemonic: WARDS, PLC).

A few causes of predominantly sensory neuropathy?
· Diabetes mellitus.
· Alcoholism.
· Deficiency of vitamins Bi2 and Bi.
· Chronic renal failure.
· Leprosy.

What are the types of neuropathy described in diabetes mellitus?
· Symmetrical, mainly sensory, polyneuropathy.
· Asymmetrical, mainly motor, polyneuropathy (diabetic amyotrophy).
· Mononeuropathy.
· Autonomic neuropathy.

What the other effects of alcohol on the central nervous system?
· Wernicke's encephalopathy (ophthalmoplegia, nystagmus, confusion and neuropathy).
· Korsakoff's psychosis (recent memory loss and confabulation).
· Cerebellar degeneration.
· Marchiafava-Bignami disease (symmetrical demyelination of corpus callosum).
· Central pontine myelinolysis.
· Amblyopia.
· Epilepsy.
· Myopathy and rhabdomyolysis.